Intravitreal Ranibizumab for myopic choroidal neovascularization after pars plana vitrectomy and silicone oil tamponade.

Abstract

PURPOSE:

To report on intravitreal Ranibizumab for intervening myopic choroidal neovascularization (CNV) in a case of retinal detachment successfully repaired with pars plana vitrectomy and silicone oil tamponade.

METHODS:

Intravitreal ranibizumab was performed in a 67-year-old woman with CNV complicating pathologic myopia. The patient had previously undergone vitrectomy and silicone oil tamponade for retinal detachment.

RESULTS:

At 2 months from intravitreal ranibizumab, best-corrected visual acuity (BCVA) improved from count fingers to 20/100, and intraocular pressure (IOP) was 16 mm Hg. Fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) showed resolution of late leakage and subretinal/intraretinal fluid, respectively.

CONCLUSIONS:

Administration of intravitreal anti-V EGF in patients with silicone oil as intraocular tamponade may represent an intriguing treatment option. Our results suggest that intravitreal injections of Ranibizumab may lead to a rapid improvement in both functional (BCVA) and morphologic (FA and SD-OCT) parameters of CNV activity, without significant rise in IOP, in eyes with silicone oil as intraocular tamponade.

• Authors: Maria Lucia Cascavilla, Giuseppe Querques, Lea Querques, Marco Codenotti, Francesco Bandello
• Journal: European journal of ophthalmology (Eur J Ophthalmol) 2013 Nov-Dec Vol. 23 Issue 6 Pg. 913-6 ISSN: 1724-6016 [Electronic] United States
• PMID: 23813105 (Publication Type: Case Reports, Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal, Humanized
• Silicone Oils
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Ranibizumab

Topics

• Aged
• Angiogenesis Inhibitors (therapeutic use)
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Choroidal Neovascularization (diagnosis, drug therapy, physiopathology)
• Endotamponade
• Female
• Fluorescein Angiography
• Humans
• Intraocular Pressure
• Intravitreal Injections
• Myopia, Degenerative (diagnosis, drug therapy, physiopathology)
• Ranibizumab
• Retinal Detachment (surgery)
• Silicone Oils (administration & dosage)
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity (physiology)
• Vitrectomy