Unique pulmonary antigen presentation may call for an alternative approach toward lung cancer immunotherapy.

Abstract

Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.

• Authors: Stephanie Chang, Xue Lin, Ryuji Higashikubo, Kelsey Toth, Andrew E Gelman, Daniel Kreisel, Alexander S Krupnick
• Journal: Oncoimmunology (Oncoimmunology) Vol. 2 Issue 3 Pg. e23563 (Mar 01 2013) ISSN: 2162-4011 [Print] United States
• PMID: 23802088 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)