Abstract | AIMS: METHODS: RESULTS: The mean weight loss was 3.8%. The incidence of weight loss >5% was 37.9% and NG tube placement was 24.3%. The factors significantly associated with >5% weight loss in the univariate analysis were tumor site (oro-hypopharyngeal vs. others), definitive vs. adjuvant RT; prescription dose of >60 Gy vs. 60 Gy; CRT vs. RT alone; prescription dose planning target volume (PTV) volume >235 cc and total PTV volume >615 cc. Age, sex, T stage, N stage and modality (3DCRT/IMRT) were not significant. In multivariate analysis, the total PTV volume, prescription dose PTV volume and use of chemotherapy were significant after controlling for other factors. Patients could be risk stratified based on the use of CRT and large PTV volumes. Patients with none, one or both factors had a likelihood of >5% weight loss of 0%, 30.3%, and 56.9% (p < 0.001) and likelihood of NG tube placement of 5.3%, 15.2% and 37.3% (p = 0.007). CONCLUSIONS: It is possible to predict weight loss and NG tube requirements from disease and treatment related factors. PTV volumes are important predictors of nutritional compromise. Risk stratification may enable more focused counseling and identification of patients who require preventive interventions.
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Authors | I Mallick, S K Gupta, R Ray, T Sinha, S Sinha, R Achari, S Chatterjee |
Journal | Clinical oncology (Royal College of Radiologists (Great Britain))
(Clin Oncol (R Coll Radiol))
Vol. 25
Issue 9
Pg. 557-63
(Sep 2013)
ISSN: 1433-2981 [Electronic] England |
PMID | 23651866
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
Topics |
- Female
- Head and Neck Neoplasms
(pathology, radiotherapy)
- Humans
- Male
- Middle Aged
- Radiotherapy, Conformal
(adverse effects)
- Retrospective Studies
- Risk Factors
- Treatment Outcome
- Weight Loss
(radiation effects)
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