Nutritional factors, physical activity, and breast cancer by hormonal receptor status.

Abstract

PURPOSE:

To investigate the association between food and nutrient intake, occupational and leisure-time physical activity, and body mass index and breast cancer risk by estrogen receptor (ER) and progesterone receptor (PR) status.

METHODS:

We analyzed data from a hospital-based case-control study conducted between 1991 and 1994 in Italy, including 1075 women with incident breast cancer and 1477 controls.

RESULTS:

The associations with breast cancer risk were similar according to ER status for all risk factors considered. In particular, significant reduced risk of ER- and ER+ breast cancers were observed for raw vegetables (multivariate odds ratio, OR, for high vs low consumption: 0.6 and 0.7, respectively) and for polyunsaturated fats (OR: 0.6 and 0.7, respectively). No significant heterogeneous risk estimates were observed for combinations of ER and PR status.

CONCLUSIONS:

Our study does not suggest major differences risk for various dietary and lifestyle factors according to ER and PR breast cancer subtypes.

• Authors: Valentina Rosato, Paola Bertuccio, Cristina Bosetti, Eva Negri, Valeria Edefonti, Monica Ferraroni, Adriano Decarli, Renato Talamini, Luigino Dal Maso, Fabio Falcini, Maurizio Montella, Silvia Franceschi, Carlo La Vecchia
• Journal: Breast (Edinburgh, Scotland) (Breast) Vol. 22 Issue 5 Pg. 887-93 (Oct 2013) ISSN: 1532-3080 [Electronic] Netherlands
• PMID: 23643804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Fatty Acids, Unsaturated
• Receptors, Estrogen
• Receptors, Progesterone
• beta Carotene
• Vitamin D
• Vitamin E
• Folic Acid

Topics

• Adult
• Aged
• Animals
• Body Mass Index
• Breast Neoplasms (chemistry, epidemiology)
• Case-Control Studies
• Diet
• Fatty Acids, Unsaturated
• Female
• Folic Acid
• Humans
• Italy (epidemiology)
• Meat Products
• Middle Aged
• Motor Activity
• Poultry
• Receptors, Estrogen (analysis)
• Receptors, Progesterone (analysis)
• Risk Factors
• Vegetables
• Vitamin D
• Vitamin E
• beta Carotene