Abstract | BACKGROUND: METHODS: Forty-eight dogs were selected for the study and two batches of 24 were blocked and allocated randomly to treatment groups and flea count times. There were four treatment groups of 12 dogs each: negative control, topical selamectin, oral spinosad/ milbemycin oxime, and oral spinosad. Each dog was infested with 100 fleas on Days -2, 7, 14, 21 and 28. Within each treatment group, six dogs were flea counted at 24 hours and six at 48 hours after treatment or post-infestation. On Day 0, dogs received a single treatment of the appropriate drug according to the approved commercial label. RESULTS: Efficacy of selamectin against an existing flea infestation was 60.4% and 91.4% at 24 and 48 hours, respectively, whereas spinosad/ milbemycin oxime and spinosad were 100% at both time points. All products were >90% effective within 24 hours after subsequent infestations on Days 7, 14 and 21. Following the Day 28 flea infestation, selamectin was 93% and 95.7% effective at 24 and 48 hours, respectively. Whereas the efficacy of spinosad/ milbemycin oxime following the day 28 infestation was 84.7% and 87.5% at 24 and 48 hours, respectively and spinosad alone was 72.9% and 76.3% effective at 24 and 48 hours, respectively. CONCLUSIONS:
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Authors | Michael W Dryden, Patricia A Payne, Vicki Smith, Thomas C Berg, Melanie Lane |
Journal | Parasites & vectors
(Parasit Vectors)
Vol. 6
Pg. 80
(Mar 25 2013)
ISSN: 1756-3305 [Electronic] England |
PMID | 23531322
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Insecticides
- Macrolides
- milbemycin oxime
- Ivermectin
- selamectin
- spinosad
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Topics |
- Administration, Oral
- Administration, Topical
- Animals
- Ctenocephalides
(drug effects)
- Dogs
- Drug Combinations
- Flea Infestations
(drug therapy, parasitology)
- Insecticides
(administration & dosage)
- Ivermectin
(administration & dosage, analogs & derivatives)
- Macrolides
(administration & dosage)
- Treatment Outcome
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