Effects of EPC capture stent and CD34+ mobilization in acute myocardial infarction.

Abstract

AIM:

Percutaneous coronary intervention (PCI) is the gold standard for the treatment of acute myocardial infarction (AMI), with the main limitation of in-stent restenosis for BMS and late stent thrombosis (ST) for both BMS and DES. Endothelial progenitor cells (EPC) CD34+ capture stents, promoting vascular healing, may be advantageous in preventing ST. Aim of the study is to evaluate the outcomes of AMI patients treated with EPC CD34+ capture stent and describe the mobilization kinetics of CD34+ and their clinical correlation.

METHODS:

Fifty AMI patients underwent primary PCI with EPC CD34+ capture stent. Serial assays of CD34+ were performed by flow-cytometric analysis.

RESULTS:

Procedural success rate was 100%. At six-months follow-up cardiac death, myocardial infarction, target lesion revascularization (TLR) and target vessel revascularization (TVR) occurred respectively in 2%, 4%, 10% and 12% of patients. No case of ST was observed. The MACE-free survival was 81,2%. The mean peak value of plasmatic CD34+ was 4.69±3.76 cells/μL. A positive correlation was found between CD34+ concentration, age and infarct area. No correlation was detected between CD34+ concentration and occurrence of TVR, TLR and MACE.

CONCLUSION:

EPC capture stent implantation seems to be safe and effective in the clinical setting of AMI, representing a possible alternative to BMS and DES. CD34+ cells plasmatic concentration seems not to correlate to coronary restenosis and atheromasic disease progression.

• Authors: P Scacciatella, M D'Amico, M Pennone, F Conrotto, E Meliga, T Usmiani, I Meynet, M Gunetti, I Ferrero, D Rustichelli, F Fagioli, S Marra
• Journal: Minerva cardioangiologica (Minerva Cardioangiol) Vol. 61 Issue 2 Pg. 211-9 (Apr 2013) ISSN: 0026-4725 [Print] Italy
• PMID: 23492604 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antigens, CD34

Topics

• Aged
• Antigens, CD34 (analysis)
• Blood Cell Count
• Comorbidity
• Coronary Restenosis (epidemiology, prevention & control, surgery)
• Coronary Thrombosis (epidemiology, prevention & control)
• Disease-Free Survival
• Endothelium, Vascular (physiology)
• Female
• Follow-Up Studies
• Hematopoietic Stem Cell Mobilization
• Humans
• Length of Stay (statistics & numerical data)
• Male
• Middle Aged
• Myocardial Infarction (mortality, surgery, therapy)
• Percutaneous Coronary Intervention (instrumentation, methods)
• Postoperative Complications (epidemiology, prevention & control)
• Prospective Studies
• Regeneration
• Registries
• Risk Factors
• Stents (adverse effects)
• Treatment Outcome