Expression of OV-6 in primary colorectal cancer and rectal cancer with preoperative chemoradiotherapy: a clinicopathological study.

Abstract

AIMS:

OV-6 is among the best available markers of liver stem cells. The aim of this study was to investigate OV-6 expression and its clinical implications in colorectal cancer.

METHODS AND RESULTS:

Expression of OV-6 and its clinical implications were investigated in 94 patients with American Joint Committee on Cancer (AJCC) stage I-III primary colorectal cancer and in 37 rectal cancer patients who had received preoperative chemoradiotherapy. The two main expression patterns of OV-6 were cytoplasmic and membranous. Overexpression of OV-6, which was identified on the basis of overall staining intensity, was associated with perineural invasion, lymphovascular invasion, and early relapses. Membranous OV-6 overexpression was also significantly associated with depth of tumour invasion, AJCC stage, lymphovascular and perineural invasion, and postoperative early relapse. Disease-free survival and overall survival were significantly poorer in patients with high overall OV-6 expression than in those with low overall OV-6 expression (P = 0.015 and P = 0.029, respectively), and significantly poorer in patients with high membranous OV-6 expression than in those with low membranous OV-6 expression (P < 0.001 and P < 0.001, respectively). Membranous OV-6 expression was a more reliable prognostic marker than overall expression.

CONCLUSIONS:

OV-6 is not unique to the hepatobiliary system, and may be a novel prognostic marker in colorectal cancer.

• Authors: Chih-Hung Lin, Chia-Hsing Liu, Hsiang-Lin Tsai, Jaw-Yuan Wang, Hung-Pei Tsai, Chee-Yin Chai
• Journal: Histopathology (Histopathology) Vol. 62 Issue 5 Pg. 742-51 (Apr 2013) ISSN: 1365-2559 [Electronic] England
• PMID: 23445514 (Publication Type: Journal Article)
• Copyright: © 2012 Blackwell Publishing Ltd.

Chemical References

• Antigens, Differentiation
• Biomarkers, Tumor
• oval cell marker OV-6

Topics

• Aged
• Antigens, Differentiation (metabolism)
• Biomarkers, Tumor (metabolism)
• Chemoradiotherapy, Adjuvant (methods)
• Colorectal Neoplasms (metabolism, mortality, pathology, therapy)
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Neoplasm Staging
• Rectal Neoplasms (metabolism, mortality, pathology, therapy)
• Retrospective Studies
• Survival Rate
• Taiwan (epidemiology)