A broad survey of cathepsin K immunoreactivity in human neoplasms.

Abstract

Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

• Authors: Gang Zheng, Guido Martignoni, Cristina Antonescu, Elizabeth Montgomery, Charles Eberhart, George Netto, Janis Taube, William Westra, Jonathan I Epstein, Tamara Lotan, Anirban Maitra, Edward Gabrielson, Michael Torbenson, Christine Iacobuzio-Donahue, Angelo Demarzo, Ie Ming Shih, Peter Illei, T C Wu, Pedram Argani
• Journal: American journal of clinical pathology (Am J Clin Pathol) Vol. 139 Issue 2 Pg. 151-9 (Feb 2013) ISSN: 1943-7722 [Electronic] England
• PMID: 23355199 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Cathepsin K

Topics

• Adenocarcinoma (metabolism, pathology)
• Adenoma (metabolism, pathology)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Renal Cell (diagnosis, metabolism)
• Cathepsin K (metabolism)
• Diagnosis, Differential
• Female
• Granular Cell Tumor (metabolism, pathology)
• Histiocytic Disorders, Malignant (metabolism, pathology)
• Humans
• Immunohistochemistry (methods)
• Kidney Neoplasms (diagnosis, metabolism)
• Male
• Melanoma (metabolism, pathology)
• Neoplasms (metabolism, pathology)
• Paraganglioma (metabolism, pathology)
• Sarcoma, Alveolar Soft Part (diagnosis, metabolism)
• Tissue Array Analysis