Abstract | BACKGROUND: MATERIAL AND METHODS: The study cohort consisted of eight patients with HNSCC who were planned for definitive radiotherapy. Hypoxic subvolumes were automatically generated on pre- radiotherapy FMISO PET scans. Three radiotherapy plans were generated for each patient: a standard (STD) radiotherapy plan to a dose of 70 Gy, a uniform dose escalation (UDE) plan to the standard target volumes to a dose of 84 Gy, and a hypoxia dose-painted (HDP) plan with dose escalation only to the hypoxic subvolume to 84 Gy. Plans were compared based on tumor control probability (TCP), normal tissue complication probability (NTCP), and uncomplicated tumor control probability (UTCP). RESULTS: The mean TCP increased from 73% with STD plans to 95% with the use of UDE plans (p < 0.001) and to 93% with HDP plans (p < 0.001). The mean parotid NTCP increased from 26% to 44% with the use of UDE plans (p = 0.003), and the mean mandible NTCP increased from 2% to 27% with the use of UDE plans (p = 0.001). There were no statistically significant differences between any of the NTCPs between the STD plans and HDP plans. The mean UTCP increased from 48% with STD plans to 66% with HDP plans (p = 0.016) and dropped to 37% with UDE plans (p = 0.138). CONCLUSION:
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Authors | Joe H Chang, Morikatsu Wada, Nigel J Anderson, Daryl Lim Joon, Sze Ting Lee, Sylvia J Gong, Dishan H Gunawardana, John Sachinidis, Graeme O'Keefe, Hui K Gan, Vincent Khoo, Andrew M Scott |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 52
Issue 8
Pg. 1723-9
(Nov 2013)
ISSN: 1651-226X [Electronic] England |
PMID | 23317145
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radiopharmaceuticals
- fluoromisonidazole
- Fluorodeoxyglucose F18
- Misonidazole
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Topics |
- Adult
- Aged
- Carcinoma, Squamous Cell
(diagnostic imaging, pathology, radiotherapy)
- Cell Hypoxia
- Cohort Studies
- Fluorodeoxyglucose F18
- Follow-Up Studies
- Head and Neck Neoplasms
(diagnostic imaging, pathology, radiotherapy)
- Humans
- Male
- Middle Aged
- Misonidazole
(analogs & derivatives)
- Models, Biological
- Neoplasm Staging
- Positron-Emission Tomography
- Prognosis
- Radiopharmaceuticals
- Radiotherapy Dosage
- Radiotherapy Planning, Computer-Assisted
- Radiotherapy, Intensity-Modulated
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