Trimeric hemibastadin congener from the marine sponge Ianthella basta.

Abstract

The first naturally occurring trimeric hemibastadin congener, sesquibastadin 1 (1), and the previously reported bastadins 3, 6, 7, 11, and 16 (2-6) were isolated from the marine sponge Ianthella basta, collected in Indonesia. The structure of 1 was elucidated on the basis of 1D and 2D NMR measurements and by HRMS. Among all the isolated compounds, the linear sesquibastadin 1 (1) and bastadin 3 (2) showed the strongest inhibition rates for at least 22 protein kinases (IC(50) = 0.1-6.5 μM), while the macrocyclic bastadins (3-6) demonstrated a strong cytotoxic potential against the murine lymphoma cell line L5178Y (IC(50) = 1.5-5.3 μM).

• Authors: Hendrik Niemann, Wenhan Lin, Werner E G Müller, Michael Kubbutat, Daowan Lai, Peter Proksch
• Journal: Journal of natural products (J Nat Prod) Vol. 76 Issue 1 Pg. 121-5 (Jan 25 2013) ISSN: 1520-6025 [Electronic] United States
• PMID: 23249297 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Halogenated Diphenyl Ethers
• Protein Kinase Inhibitors
• bastadin 6
• sesquibastadin

Topics

• Animals
• Drug Screening Assays, Antitumor
• Halogenated Diphenyl Ethers (chemistry, isolation & purification, pharmacology)
• Indonesia
• Marine Biology
• Mice
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Porifera (chemistry)
• Protein Kinase Inhibitors (chemistry, isolation & purification, pharmacology)