Plasma chromogranin A after severe burn trauma.

Abstract

BACKGROUND:

Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients.

METHODS:

Fifty-one consecutive patients with a burn area exceeding 10% were included. P-CgA was measured twice daily for seven days after injury. The point value at 24h, the mean and maximum values and the AUC at days 1-7, were tested as possible predictors. Injury severity in the form of organ dysfunction was measured as SOFA score at day 7.

RESULTS:

P-CgA could be classified into two types with respect to variability over time. Patients with high variability had more deep injuries and were older than those with low variability. All measures of CgA correlated with SOFA score at day 7, but not with total burn size. Univariate regressions showed that age, burn size and three of four measures of P-CgA predicted organ dysfunction. Multiple regressions showed that age, burn size, and either P-CgA at 24h, the mean value up to day 7, or the maximum value up to day 7, were independent predictors for organ dysfunction. Significant organ dysfunction was best predicted by age, burn area and the CgA point value at 24h with an AUC value of 0.91 in a ROC-analysis.

CONCLUSIONS:

The extent of neuroendocrine activation assessed as P-CgA after a major burn injury is independently related to organ dysfunction.

• Authors: Andreas E Lindahl, Aili Low, Mats Stridsberg, Folke Sjöberg, Lisa Ekselius, Bengt Gerdin
• Journal: Neuropeptides (Neuropeptides) Vol. 47 Issue 3 Pg. 207-12 (Jun 2013) ISSN: 1532-2785 [Electronic] Netherlands
• PMID: 23206950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Chromogranin A

Topics

• Adolescent
• Adult
• Aging (physiology)
• Area Under Curve
• Biomarkers, Tumor (blood)
• Burns (metabolism, physiopathology)
• Chromogranin A (blood)
• Female
• Humans
• Male
• Middle Aged
• Multiple Organ Failure (physiopathology)
• Neurosecretory Systems (physiopathology)
• Predictive Value of Tests
• Prognosis
• ROC Curve
• Young Adult