Liver transplant from an ABO-incompatible and hepatitis C antibody-positive but an HCV-RNA negative living donor in a familial amyloid polyneuropathy patient.

Abstract

Familial amyloid polyneuropathy is a rare, progressively disabling, and ultimately fatal inherited disease. Liver transplant is currently the only available treatment proven to halt the progression of familial amyloid polyneuropathy. We report a 31-year-old woman with familial amyloid polyneuropathy who received a living-donor liver transplant from her husband who was hepatitis C virus antibody-positive but HCV-RNA negative and ABO incompatible. Six years after the transplant, both donor and recipient have normal liver biochemistry results; no hepatitis C viral load has been detectable in the recipient. This is the first report of a living ABO-incompatible liver transplant from an anti-hepatitis C virus antibody-positive but an HCV-RNA negative donor. This experience suggests that the use of an anti-hepatitis C virus antibody-positive hepatic graft is possible in select circumstances.

• Authors: Takayuki Takeichi, Katsuhiro Asonuma, Hidekazu Yamamoto, Yuki Ohya, Kenji Okumura, Kwang-Jong Lee, Yukihiro Inomata
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 11 Issue 2 Pg. 182-5 (Apr 2013) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 23194392 (Publication Type: Case Reports, Journal Article)

Chemical References

• ABO Blood-Group System
• Hepatitis C Antibodies

Topics

• ABO Blood-Group System
• Adult
• Amyloid Neuropathies, Familial (surgery)
• Blood Group Incompatibility
• Female
• Hepacivirus (genetics, isolation & purification)
• Hepatitis C (diagnosis, immunology)
• Hepatitis C Antibodies (blood)
• Histocompatibility Testing
• Humans
• Liver Transplantation
• Living Donors
• Male
• Spouses
• Treatment Outcome