HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Carboxypeptidase M in apoptosis, adipogenesis and cancer.

Abstract
This review covers carboxypeptidase M (CPM) research that appeared in the literature since 2009. The focus is on aspects that are new or interesting from a clinical perspective. Available research tools are discussed as well as their pitfalls and limitations. Evidence is provided to suggest the potential involvement of CPM in apoptosis, adipogenesis and cancer. This evidence derives from the expression pattern of CPM and its putative substrates in cells and tissues. In recent years CPM emerged as a potential cancer biomarker, in well differentiated liposarcoma where the CPM gene is co-amplified with the oncogene MDM2; and in lung adenocarcinoma where coexpression with EGFR correlates with poor prognosis. The available data call for extended investigation of the function of CPM in tumor cells, tumor-associated macrophages, stromal cells and tumor neovascularisation. Such experiments could be instrumental to validate CPM as a therapeutic target.
AuthorsCatherine J Denis, Kathleen Deiteren, Dirk Hendriks, Paul Proost, Anne-Marie Lambeir
JournalClinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 415 Pg. 306-16 (Jan 16 2013) ISSN: 1873-3492 [Electronic] Netherlands
PMID23178445 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Biomarkers, Tumor
  • GPI-Linked Proteins
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • EGFR protein, human
  • ErbB Receptors
  • carboxypeptidase M
  • Metalloendopeptidases
Topics
  • Adenocarcinoma (blood supply, diagnosis, enzymology, genetics)
  • Adenocarcinoma of Lung
  • Adipogenesis (genetics)
  • Apoptosis (genetics)
  • Biomarkers, Tumor (genetics, metabolism)
  • ErbB Receptors (genetics, metabolism)
  • GPI-Linked Proteins (genetics, metabolism)
  • Gene Expression
  • Humans
  • Liposarcoma (blood supply, diagnosis, enzymology, genetics)
  • Lung Neoplasms (blood supply, diagnosis, enzymology, genetics)
  • Metalloendopeptidases (genetics, metabolism)
  • Neovascularization, Pathologic
  • Prognosis
  • Proto-Oncogene Proteins c-mdm2 (genetics, metabolism)
  • Signal Transduction
  • Soft Tissue Neoplasms (blood supply, diagnosis, enzymology, genetics)
  • Substrate Specificity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: