[Clinical analysis of childhood and adolescent Hodgkin's lymphoma: a report of 88 cases].

Abstract

OBJECTIVE:

The aim of this study was to investigate the clinicopathological characteristics, effective treatment and prognosis in childhood and adolescent Hodgkin's lymphoma.

METHODS:

A total of 88 patients with childhood and adolescent Hodgkin's lymphoma were treated in the Cancer Hospital of CAMS from 1998 to 2005. The clinicopathological and follow-up data of the patients were retrospectively reviewed. The survival rate was calculated by Kaplan-Meier method and compared by log-rank test. COX multivariate prognosis analysis was performed.

RESULTS:

The 2-year event-free survival rate of the 88 patients was 86.4%, the 5-year event-free survival rate was 61.4%, and the 5-year overall survival rate was 95.5%. Univariate analysis showed that the stage of disease (P = 0.033), "B" symptoms (P = 0.028), bulky disease (P = 0.007), splenomegaly (P = 0.050), LDH elevation (P = 0.020), chemotherapy regimen (P = 0.003) were prognostic factors in the 5-year event-free survival rate. Splenomegaly (P = 0.039), LDH elevation (P = 0.033), chemotherapy regimen (P = 0.008) were prognostic factors of 5-year overall survival rate. Multivariate analysis showed that chemotherapy regimen (P = 0.033), stage of disease (P = 0.023), LDH elevation (P = 0.008), "B" symptoms (P = 0.044), bulky disease (P = 0.009) were independent prognostic factors of 5-year event-free survival rate. The chemotherapy regimen (P = 0.012) and LDH elevation (P = 0.046) were independent prognostic factors of 5-year overall survival rate.

CONCLUSIONS:

The non-ABVD chemotherapy regimen, stage IV disease, LDH elevation, associated with "B" symptoms and bulky disease are independent prognostic factors of 5-year event-free survival rate. LDH elevation and non-ABVD chemotherapy regimen are independent prognostic factors of 5-year overall survival rate.

• Authors: Pu-yuan Xing, Yuan-kai Shi, Xiao-hui He, Li-qiang Zhou, Mei Dong, Jian-liang Yang, Peng Liu
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 34 Issue 9 Pg. 692-7 (Sep 2012) ISSN: 0253-3766 [Print] China
• PMID: 23159084 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bleomycin
• Procarbazine
• Mechlorethamine
• Vincristine
• Vinblastine
• Dacarbazine
• Doxorubicin
• Cyclophosphamide
• L-Lactate Dehydrogenase
• Prednisone

Topics

• Adolescent
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (therapeutic use)
• Child
• Child, Preschool
• Combined Modality Therapy
• Cyclophosphamide (therapeutic use)
• Dacarbazine (therapeutic use)
• Disease-Free Survival
• Doxorubicin (therapeutic use)
• Female
• Follow-Up Studies
• Hodgkin Disease (complications, drug therapy, pathology, radiotherapy)
• Humans
• L-Lactate Dehydrogenase (blood)
• Male
• Mechlorethamine (therapeutic use)
• Neoplasm Staging
• Prednisone (therapeutic use)
• Procarbazine (therapeutic use)
• Retrospective Studies
• Splenomegaly (etiology)
• Survival Rate
• Vinblastine (therapeutic use)
• Vincristine (therapeutic use)