Abstract | OBJECTIVE: MATERIALS AND METHODS: Data from different databases pertaining to the production of (142)Pr were compared to evaluate the accuracy of the theoretical calculations. Water-dispersible nanosized Pr(2)O(3) was prepared using a poly( ethylene glycol) (PEG) coating or PEGylation method as a successful mode of drug delivery. Radioactive (142)Pr(2)O(3) was produced via a (142)Pr(n,γ)(142)Pr reaction by thermal neutron bombardment of the prepared sample. RESULTS: There was good agreement between the reported experimental data and the data based on nuclear model calculations. In addition, a small part of nano-Pr(2)O(3) particles remained in suspension and most of them settled out of the water. Interestingly, the PEGylated Pr(2)O(3) nanoparticles were water dispersible. After neutron bombardment of the sample, a stable colloidal (142)Pr(2)O(3) was formed. CONCLUSION: The radioactive (142)Pr(2)O(3) decays to the stable (142)Nd(2)O(3). The suggested colloidal (142)Pr(2)O(3) as a multifunctional therapeutic agent could have dual roles in cancer treatment as a radiotherapeutic agent using nanosized (142)Pr(2)O(3) and as an autophagy-inducing agent using nanosized (142)Nd(2)O(3).
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Authors | Mohamadreza K Bakht, Mahdi Sadeghi, Seyed J Ahmadi, Sodeh S Sadjadi, Claudio Tenreiro |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 34
Issue 1
Pg. 5-12
(Jan 2013)
ISSN: 1473-5628 [Electronic] England |
PMID | 23104000
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Oxides
- Radioisotopes
- Radiopharmaceuticals
- Water
- Neodymium
- neodymium oxide
- Praseodymium
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Topics |
- Humans
- Nanostructures
(chemistry, therapeutic use)
- Neodymium
(chemistry, therapeutic use)
- Neoplasms
(radiotherapy)
- Neutrons
- Nuclear Medicine
(methods)
- Oxides
(chemistry, therapeutic use)
- Praseodymium
(chemistry, therapeutic use)
- Radiochemistry
(methods)
- Radioisotopes
(chemistry, therapeutic use)
- Radiopharmaceuticals
(chemistry, therapeutic use)
- Solubility
- Temperature
- Water
(chemistry)
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