Cell-based interventions for therapeutic angiogenesis: review of potential cell sources.

Abstract

Alternative therapies are currently being developed to treat patients with chronic limb ischemia who are unable to be revascularized in order to avoid amputation. Cell-based therapy using mononuclear cells is gaining attention as many clinical trials are currently underway. We review cell differentiation along with the different potential cell sources for use in therapeutic angiogenesis.

• Authors: Robert A Brenes, Mackenzie Bear, Caroline Jadlowiec, Matthew Goodwin, Peter Hashim, Clinton D Protack, Kenneth R Ziegler, Xin Li, Lynn S Model, Wei Lv, Michael J Collins, Alan Dardik
• Journal: Vascular (Vascular) Vol. 20 Issue 6 Pg. 360-8 (Dec 2012) ISSN: 1708-5381 [Print] England
• PMID: 23086985 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review)

Topics

• Animals
• Cell Differentiation
• Chronic Disease
• Extremities (blood supply)
• Humans
• Ischemia (pathology, physiopathology, surgery)
• Limb Salvage
• Neovascularization, Physiologic
• Regeneration
• Stem Cell Transplantation
• Stem Cells (pathology)
• Treatment Outcome