Short-term functional and oncological outcomes of partial nephrectomy for renal cell carcinoma in patients with an anatomically or functionally solitary kidney: single-center experience.

Abstract

BACKGROUND:

We retrospectively investigated short-term functional and oncological outcomes of partial nephrectomy (PN) for the anatomically or functionally solitary kidney in patients with renal cell carcinoma.

METHODS:

Between 1993 and 2011, 193 partial nephrectomies were performed and 16 (8.3 %) had an imperative indication in our institution. The patients' characteristics, peri- and postoperative complications, surgical margin status and postoperative changes in estimated glomerular filtration rates (eGFR) were assessed.

RESULTS:

The median follow-up period was 31.2 months and median age was 69.5 years. Open and laparoscopic PN were performed for 13 and 2 patients, respectively. One patient received ex-vivo PN followed by autotransplantation. There was no case with a positive surgical margin. All patients survived at the final day of observation. Median preoperative eGFR was 48.67 mL/min/1.73 m(2) and the reduction rate of eGFR at 3 months after operation was 20.9 % (0-50.2). Three patients (18.8 %) required temporary hemodialysis after operation and all these patients had stage 4 chronic kidney disease (CKD) before operation. Only one patient needed chronic hemodialysis at 8 months after operation.

CONCLUSIONS:

PN can be performed safely and provides feasible functional and oncological outcomes. Preoperative CKD stage 4 patients may have a risk of temporary hemodialysis in the perioperative period.

• Authors: Takeshi Maehana, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Taiji Tsukamoto
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 18 Issue 6 Pg. 1049-53 (Dec 2013) ISSN: 1437-7772 [Electronic] Japan
• PMID: 23065115 (Publication Type: Journal Article)

Topics

• Acute Kidney Injury (pathology, surgery)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Renal Cell (pathology, surgery)
• Female
• Glomerular Filtration Rate (physiology)
• Humans
• Kidney (abnormalities, pathology)
• Kidney Neoplasms (pathology, surgery)
• Male
• Middle Aged
• Nephrectomy
• Retrospective Studies
• Treatment Outcome
• Urogenital Abnormalities (pathology)