Abstract | BACKGROUND: MATERIALS AND METHODS: MIF expression was assessed by immunohistochemistry in a cohort of 154 oral cavity carcinomas and was compared to eight specimens of tumor-free epithelia, 32 cases of low-grade dysplasia and 137 cases of high-grade dysplasia. RESULTS: Marked increases in MIF-immunostaining intensity and MIF-positive tissue areas were seen in carcinomas as compared to dysplasia (p<10(-6)). MIF expression showed no correlation with recurrence, but was significantly higher (p=0.01) when a second primary tumor occurred. In addition, HPV(+) malignancies exhibited lower MIF expression. CONCLUSION: Our study revealed an association between tissue MIF levels and tumor progression in oral cavity carcinomas. Of note, high-level MIF expression was found in patients developing a second tumor during the follow-up period.
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Authors | Nadège Kindt, Jérôme Lechien, Christine Decaestecker, Alexandra Rodriguez, Gilbert Chantrain, Myriam Remmelink, Guy Laurent, Hans-Joachim Gabius, Sven Saussez |
Journal | Anticancer research
(Anticancer Res)
Vol. 32
Issue 10
Pg. 4499-505
(Oct 2012)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 23060578
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Macrophage Migration-Inhibitory Factors
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
(pathology)
- Disease Progression
- Female
- Humans
- Immunohistochemistry
- Macrophage Migration-Inhibitory Factors
(analysis, biosynthesis)
- Male
- Middle Aged
- Mouth Neoplasms
(pathology)
- Neoplasms, Second Primary
(pathology)
- Prognosis
- Young Adult
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