Abstract | OBJECTIVES: PATIENTS AND METHODS: Patients with cN0 laryngeal cancer were included. During surgery 40MBq ( 99m)Technetium labeled Nanocolloid was endoscopically injected around the tumor. Lymphoscintigraphy was not performed. We identified the sentinel node (SN) ex vivo in the neck dissection specimen with a gammaprobe. Histopathological examination of the neck dissection specimen served as reference test. RESULTS: We included 19 patients, 13 patients with untreated necks and six with prior neck treatment. SN identification was successful in 68.4% (13/19) of patients, and significantly higher in patients with untreated necks (92.3% versus 16.7%, p<0.01). Four of 13 (30.7%) patients would potentially be upstaged by SNB. Sensitivity and negative predictive value would have been 80.0% and 87.5%, respectively. CONCLUSION: With the current methodology, SN identification in laryngeal cancer patients undergoing total laryngectomy is feasible in patients with untreated necks. Further studies are needed to determine the exact accuracy of SNB in total laryngectomy patients.
|
Authors | Géke B Flach, Elisabeth Bloemena, Annelies van Schie, Otto S Hoekstra, Stijn van Weert, C René Leemans, Remco de Bree |
Journal | Oral oncology
(Oral Oncol)
Vol. 49
Issue 2
Pg. 165-8
(Feb 2013)
ISSN: 1879-0593 [Electronic] England |
PMID | 23036775
(Publication Type: Journal Article)
|
Copyright | Copyright © 2012 Elsevier Ltd. All rights reserved. |
Topics |
- Aged
- Feasibility Studies
- Humans
- Laryngeal Neoplasms
(pathology)
- Middle Aged
- Sentinel Lymph Node Biopsy
|