Abstract |
Drug adverse effects (ADEs) and toxicities have been extensively studied from chemical structure, genetic, biological systems and clinical perspectives. The rapid accumulation of chemical, biological and clinical data are highly useful for characterizing and predicting ADEs, and have enabled increasing exploration of computational methods as low cost tools for predicting various ADEs and toxicities. This article reviews the strategies, current progresses, underlying difficulties and future prospects in using computational methods for predicting ADEs and toxicities.
|
Authors | Xin Liu, Zhe Shi, Ying Xue, Ze Rong Li, Sheng Yong Yang, Yu Quan Wei, Yu Zong Chen |
Journal | Current drug safety
(Curr Drug Saf)
Vol. 7
Issue 3
Pg. 225-37
(Jul 2012)
ISSN: 2212-3911 [Electronic] United Arab Emirates |
PMID | 22950377
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
Topics |
- Drug-Related Side Effects and Adverse Reactions
- Humans
- Quantitative Structure-Activity Relationship
|