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Secondary acute myelogenous leukemia (AML) with trisomy 10 and del(9q) following precursor B-cell acute lymphoblastic leukemia (ALL) with a hyperdiploid karyotype.

Abstract
Acute myelogenous leukemia (AML) secondary to acute lymphoblastic leukemia (ALL) in children is uncommon and usually occurs within 10 years of completing therapy for ALL. A variety of recurrent cytogenetic abnormalities have been described, suggesting significant biological heterogeneity. We report a case of highly refractory secondary AML with trisomy 10 and del(9q) occurring in an adolescent female 12 years after she was treated successfully for precursor B-cell ALL with chemotherapy only.
AuthorsKarima Al-Tahou, Samir Jamil, Rajen Mody, Amy Knaus, Mark Micale, James Huang
JournalCancer genetics (Cancer Genet) Vol. 205 Issue 10 Pg. 533-6 (Oct 2012) ISSN: 2210-7762 [Print] United States
PMID22944559 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Topics
  • Adolescent
  • Child, Preschool
  • Chromosome Aberrations
  • Chromosome Banding
  • Chromosome Deletion
  • Chromosomes, Human, Pair 10
  • Chromosomes, Human, Pair 9
  • Cytogenetics
  • Diploidy
  • Fatal Outcome
  • Female
  • Humans
  • Karyotyping
  • Leukemia, Biphenotypic, Acute (genetics, pathology)
  • Leukemia, Myeloid, Acute (complications, genetics)
  • Metaphase
  • Trisomy

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