Abstract | BACKGROUND: METHODS: RESULTS: The mean age of the 609 participants was 56.4 years, and the mean baseline clinic blood pressure was 164.6/95.4 mm Hg. The primary end point analysis at week 6 demonstrated a greater reduction of clinic systolic blood pressure for the chlorthalidone (-35.1 mm Hg) versus hydrochlorothiazide combination (-29.5 mm Hg) (mean difference, -5.6 mm Hg; 95% confidence interval, -8.3 to -2.9; P <.001). The mean difference in 24-hour ambulatory systolic blood pressure at week 6 was -5.8 mm Hg (95% confidence interval, -8.4 to -3.2; P <.001), favoring the azilsartan medoxomil/ chlorthalidone group. The percentage of participants achieving target clinic blood pressure at week 6 was greater for the chlorthalidone versus hydrochlorothiazide combination (64.1% vs 45.9%, P <.001). Drug discontinuations due to adverse events were not statistically significantly different between groups (9.3% vs 7.3%, P = .38), and hypokalemia was uncommon in both groups. CONCLUSIONS:
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Authors | George L Bakris, Domenic Sica, William B White, William C Cushman, Michael A Weber, Alison Handley, Eric Song, Stuart Kupfer |
Journal | The American journal of medicine
(Am J Med)
Vol. 125
Issue 12
Pg. 1229.e1-1229.e10
(Dec 2012)
ISSN: 1555-7162 [Electronic] United States |
PMID | 22939358
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Antihypertensive Agents
- Benzimidazoles
- Drug Combinations
- Oxadiazoles
- Hydrochlorothiazide
- Creatinine
- azilsartan medoxomil
- Chlorthalidone
- Potassium
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Topics |
- Aged
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Antihypertensive Agents
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Blood Pressure Monitoring, Ambulatory
- Chlorthalidone
(therapeutic use)
- Creatinine
(blood)
- Double-Blind Method
- Drug Combinations
- Drug Therapy, Combination
- Female
- Humans
- Hydrochlorothiazide
(therapeutic use)
- Hypertension
(drug therapy)
- Male
- Middle Aged
- Oxadiazoles
(therapeutic use)
- Potassium
(blood)
- Systole
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