Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis.

Abstract

BACKGROUND:

Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state.

METHODS:

Adult patients with CF were studied immediately preceding and following 2 weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured.

RESULTS:

Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01).

CONCLUSION:

The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

• Authors: James H Hull, Rachel Garrod, Timothy B Ho, Ronald K Knight, John R Cockcroft, Dennis J Shale, Charlotte E Bolton
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 12 Issue 2 Pg. 125-9 (Mar 2013) ISSN: 1873-5010 [Electronic] Netherlands
• PMID: 22858239 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• C-Reactive Protein

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage)
• Arteries (drug effects, pathology)
• Blood Pressure (drug effects, physiology)
• C-Reactive Protein (metabolism)
• Cystic Fibrosis (drug therapy, pathology)
• Female
• Heart Rate (drug effects, physiology)
• Hemodynamics (drug effects, physiology)
• Humans
• Infusions, Intravenous
• Male
• Spirometry