Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice.

Abstract

White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.

• Authors: Xiaoying Bi, Yanbo Zhang, Bin Yan, Shaokuan Fang, Jue He, Dai Zhang, Zhijun Zhang, Jiming Kong, Qingrong Tan, Xin-Min Li
• Journal: Journal of neurochemistry (J Neurochem) Vol. 123 Issue 1 Pg. 14-20 (Oct 2012) ISSN: 1471-4159 [Electronic] England
• PMID: 22817262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry.

Chemical References

• Antigens
• Antipsychotic Agents
• Dibenzothiazepines
• Glial Fibrillary Acidic Protein
• Myelin Basic Protein
• Proteoglycans
• chondroitin sulfate proteoglycan 4
• Quetiapine Fumarate
• Bromodeoxyuridine

Topics

• Analysis of Variance
• Animals
• Antigens (metabolism)
• Antipsychotic Agents (administration & dosage)
• Brain Ischemia (etiology, pathology, prevention & control)
• Bromodeoxyuridine (metabolism)
• Carotid Artery Diseases (complications)
• Cell Differentiation (drug effects)
• Dibenzothiazepines (administration & dosage)
• Disease Models, Animal
• Gene Expression Regulation (drug effects)
• Glial Fibrillary Acidic Protein (metabolism)
• Hippocampus (drug effects, pathology)
• Male
• Mice
• Myelin Basic Protein (metabolism)
• Myelin Sheath (metabolism)
• Oligodendroglia (drug effects)
• Proteoglycans (metabolism)
• Quetiapine Fumarate
• Time Factors