The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo.

Abstract

This study focuses on determining whether the combination of NYP-BKM120 (BKM120) and RAD001 exerts enhanced therapeutic effect against lung cancer. The combination of BKM120 and RAD001 exerted synergistic inhibitory effects on the growth of lung cancer cells both in culture and in mouse xenograft model. This combination abrogated RAD001-induced Akt phosphorylation and exerted enhanced suppressive effect on 4EBP1 phosphorylation. Collectively, we suggest that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic.

• Authors: Hui Ren, Mingwei Chen, Ping Yue, Hui Tao, Taofeek K Owonikoko, Suresh S Ramalingam, Fadlo R Khuri, Shi-Yong Sun
• Journal: Cancer letters (Cancer Lett) Vol. 325 Issue 2 Pg. 139-46 (Dec 28 2012) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 22781393 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Aminopyridines
• Culture Media, Serum-Free
• Immunosuppressive Agents
• Morpholines
• NVP-BKM120
• Neoplasm Proteins
• Phosphoinositide-3 Kinase Inhibitors
• Protein Kinase Inhibitors
• Recombinant Fusion Proteins
• Everolimus
• MTOR protein, human
• AKT1 protein, human
• Proto-Oncogene Proteins c-akt
• TOR Serine-Threonine Kinases
• Sirolimus

Topics

• Aminopyridines (administration & dosage, pharmacology)
• Animals
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Cell Line, Tumor
• Culture Media, Serum-Free
• Drug Synergism
• Everolimus
• G1 Phase (drug effects)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Immunosuppressive Agents (administration & dosage, pharmacology)
• Lung Neoplasms (drug therapy, pathology)
• Male
• Mice
• Mice, Nude
• Morpholines (administration & dosage, pharmacology)
• Neoplasm Proteins (antagonists & inhibitors, physiology)
• Phosphoinositide-3 Kinase Inhibitors
• Phosphorylation (drug effects)
• Protein Kinase Inhibitors (administration & dosage, pharmacology)
• Protein Processing, Post-Translational (drug effects)
• Proto-Oncogene Proteins c-akt (antagonists & inhibitors, genetics, physiology)
• Recombinant Fusion Proteins (antagonists & inhibitors, genetics)
• Signal Transduction (drug effects)
• Sirolimus (administration & dosage, analogs & derivatives, pharmacology)
• TOR Serine-Threonine Kinases (antagonists & inhibitors)
• Tumor Stem Cell Assay
• Xenograft Model Antitumor Assays