Duarte galactose-1-phosphate uridyl transferase genotypes are not associated with ovarian cancer risk.

Abstract

OBJECTIVE:

To investigate whether galactose-1-phosphate uridyl transferase (GALT) variant genotypes were associated with epithelial ovarian cancer risk, and to determine if this association was modified by lactose intake.

DESIGN:

Two prospective cohort studies and a case-control study.

SETTING:

Academic institution.

PATIENT(S):

A total of 992 cases and 1,050 population-based control samples from a New England case-control study and 240 cases and 900 control samples from the Nurses' Health Studies.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Genotyping of the N314D variant and the 4-bp deletion (-119delGTCA) of GALT with the use of the Taqman 5' nuclease assay. Duarte1 (D1) genotype individuals have a missense mutation (N314D) associated with normal GALT activity unless it occurs together with an associated 4-bp deletion leading to reduced GALT activity (Duarte2 or D2).

RESULT(S):

Logistic regression analysis identified no association between D1/D2 genotypes and ovarian cancer risk (pooled risk ratio 1.1 [95% confidence interval (CI) 0.8-1.5] for D1 and 1.0 [95% CI 0.7-1.4] for D2). We did not observe a significant interaction between D1 and D2 genotypes in analyses stratified by level of lactose intake.

CONCLUSION(S):

D1 and D2 genotypes do not appear to play a role in the association between galactose intake, possible ovarian dysfunction, and the link with ovarian cancer.

• Authors: Melissa A Merritt, Joanne Kotsopoulos, Daniel W Cramer, Susan E Hankinson, Kathryn L Terry, Shelley S Tworoger
• Journal: Fertility and sterility (Fertil Steril) Vol. 98 Issue 3 Pg. 687-91 (Sep 2012) ISSN: 1556-5653 [Electronic] United States
• PMID: 22749219 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Chemical References

• UTP-Hexose-1-Phosphate Uridylyltransferase

Topics

• Adult
• Case-Control Studies
• Cohort Studies
• Female
• Genotype
• Humans
• Middle Aged
• Ovarian Neoplasms (etiology, genetics)
• Prospective Studies
• Risk
• UTP-Hexose-1-Phosphate Uridylyltransferase (genetics)