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From loss to gain: role for SUN1 in laminopathies.

Abstract
Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function versus a loss-of-function model for the action of lamin A mutants.
AuthorsBaohua Liu, Dong-Yan Jin, Zhongjun Zhou
JournalCell & bioscience (Cell Biosci) Vol. 2 Issue 1 Pg. 21 (Jun 18 2012) ISSN: 2045-3701 [Electronic] England
PMID22709970 (Publication Type: Journal Article)

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