Abstract |
Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies. A recent study showed that mis-accumulation of SUN1 underlies the pathology of degenerative features in laminopathies, and concomitantly suggests a gain-of-function versus a loss-of-function model for the action of lamin A mutants.
|
Authors | Baohua Liu, Dong-Yan Jin, Zhongjun Zhou |
Journal | Cell & bioscience
(Cell Biosci)
Vol. 2
Issue 1
Pg. 21
(Jun 18 2012)
ISSN: 2045-3701 [Electronic] England |
PMID | 22709970
(Publication Type: Journal Article)
|