Pre-transplant myeloid dendritic cell deficiency associated with cytomegalovirus infection and death after kidney transplantation.

Abstract

BACKGROUND:

Dendritic cells (DCs) are potent antigen-presenting cells critical for immunity. We previously demonstrated a significant association between pre-transplant blood myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) deficiency and post-transplant BK viremia in renal transplant recipients. In the current post-hoc analysis, we studied the association of these same pre-transplant DC levels with other post-transplant outcomes.

METHODS:

Pre-transplant peripheral blood mDC and pDC levels were quantified using flow cytometry in 78 patients undergoing kidney transplantation. Post-transplant outcomes were analyzed, including infection, rejection, and patient death, with a median follow-up of 5.3 years. Associations between DC levels and outcomes were assessed using logistic regression analysis and Cox proportional hazards models.

RESULTS:

An independent association of mDC levels with post-transplant cytomegalovirus infection (adjusted odds ratio 7.0, P = 0.01) and patient death (adjusted hazard ratio 13.0, P = 0.015) was found. No associations were demonstrated between levels of either DC subtype and bacterial infections or rejection.

CONCLUSIONS:

Pre-transplant mDC deficiency is significantly associated with CMV infection and death after kidney transplantation.

• Authors: Q Sun, E C Hall, Y Huang, P Chen, K Dibadj, M Murawski, R Shraybman, K Van Kirk, V Tang, R Peng, P R Patton, M J Clare-Salzler, B Kaplan, D L Segev, K L Womer
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 14 Issue 6 Pg. 618-25 (Dec 2012) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 22672201 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S.

Topics

• Adult
• Cytomegalovirus Infections (etiology, mortality)
• Dendritic Cells (physiology)
• Female
• Humans
• Kidney Transplantation (adverse effects, mortality)
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Risk Factors