Hortonones A to C, hydroazulenones from the genus Hortonia.

Abstract

The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton, and hortonone C (3) has the unprecedented rearranged and degraded 13-norhortonane skeleton. Hortonone C (3) exhibited in vitro cytotoxicity against human breast cancer MCF-7 cells at 5 μg/mL.

• Authors: Gavin Carr, David E Williams, Rukmal Ratnayake, Ratnayake Bandara, Siril Wijesundara, Tamsin Tarling, Aruna D Balgi, Michel Roberge, Raymond J Andersen, Veranja Karunaratne
• Journal: Journal of natural products (J Nat Prod) Vol. 75 Issue 6 Pg. 1189-91 (Jun 22 2012) ISSN: 1520-6025 [Electronic] United States
• PMID: 22626446 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Diterpenes
• hortonone A
• hortonone B
• hortonone C

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Breast Neoplasms
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Female
• Humans
• Molecular Structure
• Monimiaceae (chemistry)
• Plant Leaves (chemistry)
• Sri Lanka