HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The palliative role of PDT in recurrent advanced nasopharyngeal carcinoma: case series.

Abstract
We report on the application of photodynamic therapy in the management of recurrent advanced carcinoma of the nasopharynx. A selected cohort of 7 patients, only suitable for palliative therapy, was offered this modality to assess the palliative role of PDT. All 7 patients had at least 2 previous recurrences, which were managed with surgery and chemoradiotherapy but ultimately failed to respond. PDT was offered after careful discussion at a multidiscipline meeting. The photosensitiser "mTHPC" was introduced intravenously 96 h prior to delivering the light with nasoendoscopic guidance. Six patients' symptoms were reduced markedly post photodynamic therapy. Five patients have to had another round of treatment which was found to be as effective as the first round in terms of controlling disease progression as well as symptoms. Magnetic resonance images showed variable reduction of tumour volume with the majority of the patients having moderate to significant response. Photodynamic therapy was very successful palliative therapy for this small group of recurrent advanced nasopharyngeal cancer patients.
AuthorsSyedda Abbas, Waseem Jerjes, Tahwinder Upile, Francis Vaz, Colin Hopper
JournalPhotodiagnosis and photodynamic therapy (Photodiagnosis Photodyn Ther) Vol. 9 Issue 2 Pg. 142-7 (Jun 2012) ISSN: 1873-1597 [Electronic] Netherlands
PMID22594984 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Mesoporphyrins
  • Photosensitizing Agents
  • temoporfin
Topics
  • Adult
  • Carcinoma
  • Humans
  • Male
  • Mesoporphyrins (therapeutic use)
  • Middle Aged
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Neoplasms (diagnosis, drug therapy, prevention & control)
  • Neoplasm Recurrence, Local (diagnosis, drug therapy, prevention & control)
  • Palliative Care (methods)
  • Photochemotherapy (methods)
  • Photosensitizing Agents (therapeutic use)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: