Abstract |
We report on the application of photodynamic therapy in the management of recurrent advanced carcinoma of the nasopharynx. A selected cohort of 7 patients, only suitable for palliative therapy, was offered this modality to assess the palliative role of PDT. All 7 patients had at least 2 previous recurrences, which were managed with surgery and chemoradiotherapy but ultimately failed to respond. PDT was offered after careful discussion at a multidiscipline meeting. The photosensitiser " mTHPC" was introduced intravenously 96 h prior to delivering the light with nasoendoscopic guidance. Six patients' symptoms were reduced markedly post photodynamic therapy. Five patients have to had another round of treatment which was found to be as effective as the first round in terms of controlling disease progression as well as symptoms. Magnetic resonance images showed variable reduction of tumour volume with the majority of the patients having moderate to significant response. Photodynamic therapy was very successful palliative therapy for this small group of recurrent advanced nasopharyngeal cancer patients.
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Authors | Syedda Abbas, Waseem Jerjes, Tahwinder Upile, Francis Vaz, Colin Hopper |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 9
Issue 2
Pg. 142-7
(Jun 2012)
ISSN: 1873-1597 [Electronic] Netherlands |
PMID | 22594984
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- Mesoporphyrins
- Photosensitizing Agents
- temoporfin
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Topics |
- Adult
- Carcinoma
- Humans
- Male
- Mesoporphyrins
(therapeutic use)
- Middle Aged
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms
(diagnosis, drug therapy, prevention & control)
- Neoplasm Recurrence, Local
(diagnosis, drug therapy, prevention & control)
- Palliative Care
(methods)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(therapeutic use)
- Treatment Outcome
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