[Retrospective analysis of the safety of four hours administration of liposomal amphotericin B in patients with chronic necrotizing pulmonary aspergillosis].
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| Abstract |
We have retrospectively analyzed the safety of 4 hours administration of liposomal amphotericin B (L-AMB) compared to less than or equal to 3 hours administration in patients with chronic necrotizing pulmonary aspergillosis (CNPA). The elevation of serum creatinine in the group with 4 hours administration of L-AMB in patients with CNPA was equal to the group with shorter administration time (less than or equal to three hours). During the administration of L-AMB, the group with 4 hours administration of LAMB had significantly a safer profile in relation to hypokalemia during L-AMB treatment than the group with shorter administration time. Additionally, white cell counts, platelet counts, serum creatinine, AST, ALT were not significantly different between L-AMB 4 hours administration group and less than or equal to 3 hours administration group. As the group with 4 hours administration of L-AMB had significantly a safer profile in relation to hypokalemia during L-AMB treatment, this modality can be one of the safer ways in the treatment of CNPA. As L-AMB is one of the fungicidal agents, 4 hours administration of L-AMB can be an optimal way of treating CNPA.
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| Authors | Kazuhiro Yatera, Kei Yamasaki, Minako Kozaki, Makiko Shimauchi, Toshinori Kawanami, Shuya Nagata, Yu Suzuki, Susumu Tokuyama, Naomasa Inoue, Chinatsu Nishida, Hiroshi Ishimoto, Tatsunori Kawajiri, Yukikazu Awaya, Toru Tsuda, Hiroshi Mukae |
| Journal | The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 64 Issue 5 Pg. 311-8 (Oct 2011) ISSN: 0368-2781 [Print] Japan |
| PMID | 22428214 (Publication Type: English Abstract, Journal Article) |
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