Abstract |
Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.
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Authors | Daniel Golparian, Prabhavathi Fernandes, Makoto Ohnishi, Jörgen S Jensen, Magnus Unemo |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 56
Issue 5
Pg. 2739-42
(May 2012)
ISSN: 1098-6596 [Electronic] United States |
PMID | 22354296
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- Culture Media
- Macrolides
- Triazoles
- Erythromycin
- solithromycin
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Topics |
- Anti-Bacterial Agents
(chemistry, pharmacology)
- Cephalosporin Resistance
- Cephalosporins
(pharmacology)
- Culture Media
- Drug Resistance, Multiple, Bacterial
(drug effects)
- Erythromycin
(pharmacology)
- Humans
- Macrolides
(chemistry, pharmacology)
- Microbial Sensitivity Tests
- Molecular Structure
- Neisseria gonorrhoeae
(drug effects, growth & development, isolation & purification)
- Triazoles
(chemistry, pharmacology)
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