Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis.

Abstract

In addition to its proapoptotic function, caspase-8 is also important for several other processes, including suppressing necroptosis, cell migration, and immune cell survival. In the present study, we report that the loss of caspase-8 in B lymphocytes leads to B-cell malignancies and that the risk for these tumors is further enhanced in the absence of p53. We also report that deficiency of caspase-8 results in impaired cytokinesis and that casp8(-/-) lymphomas display remarkably elevated levels of chromosomal aberrations. Our data support an important role for caspase-8 in the maintenance of genomic integrity and highlight its tumor-suppressive function.

• Authors: Anne Hakem, Samah El Ghamrasni, Georges Maire, Benedicte Lemmers, Jana Karaskova, Andrea Jurisicova, Otto Sanchez, Jeremy Squire, Razqallah Hakem
• Journal: Blood (Blood) Vol. 119 Issue 15 Pg. 3495-502 (Apr 12 2012) ISSN: 1528-0020 [Electronic] United States
• PMID: 22343728 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Casp8 protein, mouse
• Caspase 8

Topics

• 3T3 Cells
• Animals
• Autoimmune Lymphoproliferative Syndrome (complications, genetics, immunology, pathology)
• B-Lymphocytes (immunology, metabolism, physiology)
• Caspase 8 (genetics, physiology)
• Cells, Cultured
• Chromosomal Instability (genetics)
• Down-Regulation (genetics, immunology)
• Genes, p53 (physiology)
• Genetic Predisposition to Disease
• Lymphoma, B-Cell (etiology, genetics, mortality, pathology)
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Survival Analysis