Abstract | OBJECTIVE: DESIGN: This double-blinded, placebo-controlled inpatient study evaluated the effects of 0, 30, and 60 mg of dextromethorphan and quinidine (DMQ) on the reinforcing and subjective effects of heroin in recently detoxified heroin abusers. PARTICIPANTS: Nine heroin-dependent participants were admitted and then detoxified from heroin over the course of several days. INTERVENTIONS: Participants were subsequently stabilized on 0, 30, or 60 mg of DMQ. Each dose of DMQ was administered for two consecutive weeks, and the effects of heroin (0, 12.5, and 50 mg) were studied under each DMQ maintenance dose condition. DMQ and heroin dose were administered in random order both within and between participants. RESULTS: Planned comparisons revealed statistically significant increases in progressive ratio breakpoint values and positive subjective ratings as a function of heroin dose. There were no consistent changes in any of the responses as a function of DMQ maintenance dose, other than a modest reduction in craving. CONCLUSIONS:
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Authors | Suzanne K Vosburg, Maria A Sullivan, Sandra D Comer |
Journal | Journal of opioid management
(J Opioid Manag)
2011 Nov-Dec
Vol. 7
Issue 6
Pg. 451-61
ISSN: 1551-7489 [Print] United States |
PMID | 22320027
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
- Drug Combinations
- Excitatory Amino Acid Antagonists
- dextromethorphan - quinidine combination
- Heroin
- Dextromethorphan
- Quinidine
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Topics |
- Adult
- Dextromethorphan
(administration & dosage, pharmacology)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Combinations
- Excitatory Amino Acid Antagonists
(administration & dosage, pharmacology)
- Heroin
(administration & dosage, pharmacology)
- Heroin Dependence
(rehabilitation)
- Humans
- Male
- Quinidine
(administration & dosage, pharmacology)
- Reinforcement, Psychology
- Self Administration
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