Mayer-Rokitansky-Küster-Hauser syndrome: a review of 245 consecutive cases managed by a multidisciplinary approach with vaginal dilators.

Abstract

OBJECTIVE:

To understand the efficacy of vaginal dilators in the management of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.

DESIGN:

Retrospective sequential study.

SETTING:

Hospital.

PATIENT(S):

245 women.

INTERVENTION(S):

Vaginal dilators.

MAIN OUTCOME MEASURE(S):

Functional vaginal length and sexual satisfaction.

RESULT(S):

Of the patients who completed the program, 232 (94.9%) achieved a successful vaginal length (defined as greater than 6 cm in length and maximum width throughout the vagina and especially at the apex) and sexual function. When the program was completed by all patients, 100% of patients were successful.

CONCLUSION(S):

Vaginal dilator therapy is the treatment of first choice for creation of the vagina in MRKH syndrome, and the success rates suggest that surgery is rarely, if ever, required.

• Authors: D Keith Edmonds, Gillian L Rose, Michelle G Lipton, Julie Quek
• Journal: Fertility and sterility (Fertil Steril) Vol. 97 Issue 3 Pg. 686-90 (Mar 2012) ISSN: 1556-5653 [Electronic] United States
• PMID: 22265001 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Topics

• 46, XX Disorders of Sex Development (physiopathology, therapy)
• Abnormalities, Multiple (physiopathology, therapy)
• Adolescent
• Adult
• Congenital Abnormalities
• Dilatation (adverse effects, instrumentation)
• Female
• Humans
• Kidney (abnormalities)
• London
• Middle Aged
• Mullerian Ducts (abnormalities)
• Patient Care Team
• Patient Satisfaction
• Recovery of Function
• Retrospective Studies
• Sexual Behavior
• Somites (abnormalities)
• Spine (abnormalities)
• Surveys and Questionnaires
• Time Factors
• Treatment Outcome
• Uterus (abnormalities, physiopathology)
• Vagina (abnormalities, physiopathology)
• Young Adult