Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation.

Abstract

We improved the specific radioactivity of the apoptosis imaging isatin derivative (18)F-ICMT11. We then evaluated (18)F-ICMT11 in EL4 tumor-bearing mice 24h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115±0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083±0.008 SUV). This effect correlated to the observed increases in apoptotic index.

• Authors: Matthias Glaser, Julian Goggi, Graham Smith, Matthew Morrison, Sajinder K Luthra, Edward Robins, Eric O Aboagye
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 21 Issue 23 Pg. 6945-9 (Dec 01 2011) ISSN: 1464-3405 [Electronic] England
• PMID: 22030029 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Ltd. All rights reserved.

Chemical References

• (18)F-ICMT11
• Azides
• Biomarkers
• Indoles
• Radiopharmaceuticals
• Fluorodeoxyglucose F18
• Isatin

Topics

• Animals
• Apoptosis
• Azides (chemical synthesis, chemistry)
• Biomarkers (chemistry)
• Diagnostic Imaging
• Disease Models, Animal
• Fluorodeoxyglucose F18
• Indoles (chemical synthesis, chemistry)
• Isatin (chemistry)
• Lymphoma (diagnostic imaging)
• Mice
• Molecular Structure
• Positron-Emission Tomography
• Radiopharmaceuticals (chemical synthesis, chemistry)