Chronic toxicity of erythromycin thiocyanate to Daphnia magna in a flow-through, continuous exposure test system.

Abstract

Approval of a new animal drug application for AQUAMYCIN 100(®) (erythromycin thiocyanate; ET) to treat freshwater salmonid species with bacterial kidney disease is being pursued in the US. As part of the approval process, ET's impact on an aquatic environment had to be described in an environmental assessment. The environmental assessment was lacking data to characterize the effect ET would have on a chronically exposed aquatic invertebrate organism. A major step to fulfilling the environmental assessment was completed after conducting a comprehensive study continuously exposing Daphnia magna to ET for 21 days. Results indicated that the no observable effect concentration for ET was 179 μg/L.

• Authors: Jeffery R Meinertz, Theresa M Schreier, Jeffry A Bernardy
• Journal: Bulletin of environmental contamination and toxicology (Bull Environ Contam Toxicol) Vol. 87 Issue 6 Pg. 621-5 (Dec 2011) ISSN: 1432-0800 [Electronic] United States
• PMID: 21984684 (Publication Type: Journal Article)

Chemical References

• Water Pollutants, Chemical
• Erythromycin
• erythromycin thiocyanate

Topics

• Animals
• Daphnia (drug effects)
• Dose-Response Relationship, Drug
• Environmental Monitoring (methods)
• Erythromycin (analogs & derivatives, toxicity)
• Fresh Water (chemistry)
• Reproduction (drug effects)
• Toxicity Tests, Chronic (methods)
• Water Pollutants, Chemical (toxicity)