[A case of malignant tumor of the ascending part of duodenum with osteoclast-like giant cells].

Abstract

Extraskeletal neoplasms with osteoclast-like giant cells are very rare. These tumors are most frequently reported in the breast and pancreas, and but rarely in other sites. We report a case of duodenal malignant tumor with osteoclast-like giant cells. The patient was a 76-year-old man who presented with vomiting. Computed tomography, magnetic resonance imaging, and gastrointestinal endoscopy revealed a giant tumor in the ascending part of duodenum. Biopsy specimens showed an undifferentiated malignant tumor with benign multinucleated giant cells. Immunohistochemical staining indicated that the tumor cells were reactive with vimentin, but not with epithelial markers or the other mesenchymal markers, and the multinucleated giant cells were reactive with CD68. Thus, we diagnosed a malignant tumor of the ascending part of duodenum with osteoclast-like giant cells. To the best of our knowledge, this is the first case of duodenal malignant tumor with osteoclast-like giant cells in Japan.

• Authors: Atsuyuki Hirano, Kenji Tsuchida, Makoto Nakamura, Kazunori Adachi, Yusuke Inagaki, Yoshihiro Yamakawa, Hiroki Kawai, Yoshihide Kimura, Kyoji Seno, Isao Kosugi, Kohei Katsumi
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 108 Issue 10 Pg. 1705-11 (Oct 2011) ISSN: 0446-6586 [Print] Japan
• PMID: 21971144 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Duodenal Neoplasms (pathology)
• Giant Cell Tumors (pathology)
• Humans
• Male
• Osteoclasts (pathology)