Evidence for the use of l-methylfolate combined with antidepressants in MDD.

Abstract

Helping patients with major depressive disorder achieve symptom-free remission with antidepressant therapy remains challenging. In this activity, 3 investigators discuss the results of a 2-trial, multicenter, randomized, double-blind, placebo-controlled study of adjunctive l-methylfolate, the bioavailable form of folate, in patients who had inadequately responded to an SSRI. The efficacy of doses of 7.5 mg/d versus 15 mg/d is examined, and the safety and tolerability of l-methylfolate are compared with those of other adjunctive treatments. Different types of folate are explained, and the characteristics of patients who might benefit from adjunctive l-methylfolate are proposed.

• Authors: Maurizio Fava, Richard C Shelton, John M Zajecka
• Journal: The Journal of clinical psychiatry (J Clin Psychiatry) Vol. 72 Issue 8 Pg. e25 (Aug 2011) ISSN: 1555-2101 [Electronic] United States
• PMID: 21899813 (Publication Type: Interactive Tutorial)
• Copyright: © Copyright 2011 Physicians Postgraduate Press, Inc.

Chemical References

• Antidepressive Agents
• Folic Acid

Topics

• Antidepressive Agents (administration & dosage, chemistry)
• Depressive Disorder, Major (drug therapy)
• Dose-Response Relationship, Drug
• Double-Blind Method
• Drug Therapy, Combination
• Folic Acid (administration & dosage, chemistry)
• Humans
• Multicenter Studies as Topic
• Patient Selection
• Randomized Controlled Trials as Topic