Significant correlation of peptidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients.

Abstract

BACKGROUND:

An overexpression of PIN1, the peptidyl-prolyl cis-trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor.

METHODS:

Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease-free survival of patients.

RESULTS:

All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression (p = .031), but expression was not significant for disease-free survival (p = .821). The 5-year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1.

CONCLUSIONS:

PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC.

• Authors: Claudia Lill, Sven Schneider, Johannes Pammer, Robert Loewe, Wilhelm Gedlicka, Roland Houben, Gregor Heiduschka, Markus Brunner, Dietmar Thurnher
• Journal: Head & neck (Head Neck) Vol. 33 Issue 9 Pg. 1294-300 (Sep 2011) ISSN: 1097-0347 [Electronic] United States
• PMID: 21837699 (Publication Type: Journal Article)
• Copyright: Copyright © 2010 Wiley Periodicals, Inc.

Chemical References

• NIMA-Interacting Peptidylprolyl Isomerase
• PIN1 protein, human
• Peptidylprolyl Isomerase

Topics

• Aged
• Aged, 80 and over
• Carcinoma, Merkel Cell (enzymology, mortality, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• NIMA-Interacting Peptidylprolyl Isomerase
• Peptidylprolyl Isomerase (metabolism)
• Prognosis
• Retrospective Studies
• Skin Neoplasms (enzymology, mortality, pathology)
• Survival Analysis