Abstract | BACKGROUND: METHODS: This nested case-control study investigated whether serum selenium concentration and genetic variants in five selenoenzymes ( glutathione peroxidase 1-4 and selenoprotein P) were associated with colorectal cancer risk in 804 colorectal cancer cases and 805 matched controls from the Women's Health Initiative (WHI) Observational Study. A meta-analysis was conducted to compare the WHI result with previous studies including 12 observational studies and two clinical trials on selenium. RESULTS: Within the WHI, selenium concentrations were relatively high (mean = 135.6 μg/L) and were not associated with colorectal cancer risk (P(trend) = 0.10); the adjusted OR comparing the fifth with first quintile was 1.26 (95% CI, 0.91-1.73). Moreover, genetic variants in selenoenzymes were not significantly associated with colorectal cancer risk. Consistent with the finding in WHI, our meta-analysis showed no association between selenium and colorectal tumor risk in women (OR = 0.97; 95% CI, 0.79-1.18) comparing the highest quantile with the lowest); however, in men, there was a significant inverse association (OR = 0.68; 95% CI, 0.57-0.82) (P = 0.01). CONCLUSION: IMPACT: Our analyses suggest that a population with relatively high selenium concentrations, especially women, would not benefit from increasing selenium intake.
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Authors | Yumie Takata, Alan R Kristal, Irena B King, Xiaoling Song, Alan M Diamond, Charles B Foster, Carolyn M Hutter, Li Hsu, David J Duggan, Robert D Langer, Helen Petrovitch, James M Shikany, Thomas L Vaughan, Johanna W Lampe, Ross L Prentice, Ulrike Peters |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 20
Issue 9
Pg. 1822-30
(Sep 2011)
ISSN: 1538-7755 [Electronic] United States |
PMID | 21765007
(Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Selenoprotein P
- Glutathione Peroxidase
- Selenium
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Topics |
- Aged
- Case-Control Studies
- Colorectal Neoplasms
(blood, enzymology, epidemiology, genetics)
- Female
- Genetic Predisposition to Disease
- Glutathione Peroxidase
(genetics)
- Humans
- Male
- Middle Aged
- Risk Factors
- Selenium
(blood)
- Selenoprotein P
(genetics)
- United States
(epidemiology)
- Women's Health
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