Abstract |
The assessment of bone marrow involvement (BMI) is important for accurate prognostication and deciding the appropriate therapy in patients with lymphoma. Conventional bilateral iliac crest biopsies (ILBMBs) have many limitations. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful investigative tool for detecting BMI. F-18 FDG PET/CT data for 97 patients with either non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) were analyzed. ILBMB was performed 7-10 days later. A final diagnosis of BMI was made in 38/97 patients on the basis of composite criteria derived from both FDG PET/CT and ILBMB results. ILBMB detected BMI in 29/38 patients, 2/5 patients with HL, 27/33 patients with NHL, 19/25 patients with aggressive NHL, and 8/8 patients with indolent NHL with a sensitivity of 76%, 40%, 82%, 76%, and 100%, respectively. FDG PET/CT was true positive for BMI in 5/5 patients with HL and 29/33 patients with NHL, comprising 25/25 patients with aggressive NHL and 4/8 patients with indolent NHL, with a sensitivity of 100%, 88%, 100%, and 50%, respectively. FDG PET/CT performed better than ILBMB in cases of HL and aggressive NHL, but its sensitivity was poor in cases of indolent lymphoma. In addition, FDG PET/CT had a very high negative predictive value approaching 100% in HL and aggressive NHL, which might help in avoiding negative ILBMBs.
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Authors | Bhagwant Rai Mittal, Kuruva Manohar, Pankaj Malhotra, Reena Das, Raghava Kashyap, Anish Bhattacharya, Neelam Varma, Subhash Varma |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 52
Issue 11
Pg. 2111-6
(Nov 2011)
ISSN: 1029-2403 [Electronic] United States |
PMID | 21745169
(Publication Type: Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Algorithms
- Biopsy
- Bone Marrow
(diagnostic imaging, pathology)
- Female
- Fluorodeoxyglucose F18
- Hodgkin Disease
(diagnostic imaging, pathology)
- Humans
- Ilium
(pathology)
- Lymphoma, Non-Hodgkin
(diagnostic imaging, pathology)
- Male
- Positron-Emission Tomography
(methods)
- Prognosis
- Radiopharmaceuticals
- Reproducibility of Results
- Sensitivity and Specificity
- Tomography, X-Ray Computed
(methods)
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