Abstract | BACKGROUND: Genetic factors contributing to the development of IgA nephropathy remain to be elucidated. METHODS: The present multicenter cross-sectional case-control study measured genotype frequencies of 65 atherosclerotic disease-related gene polymorphisms in 230 Japanese patients with IgA nephropathy and 262 apparently healthy volunteers with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m(2) and negative or trace proteinuria and hematuria by dipstick test [non- chronic kidney disease (CKD) participants]. Clinical characteristics at kidney biopsy of patients with IgA nephropathy and those at the study recruitment of non-CKD participants were included as covariates in multivariate logistic regression models. RESULTS: Among 31 gene polymorphisms with ≥5% of minor genotype in non-CKD participants, methionine synthase MTR A2756G (D919G) was significantly associated with IgA nephropathy using χ(2) test even after controlling for family-wise error rate by the method of Bonferroni (P = 0.044). A multivariate nonconditional logistic regression model identified MTR A2756G as a significant contributor of IgA nephropathy [2756AG and GG versus AA, odds ratio 0.42 (95% confidence interval 0.25-0.69) and 0.21 (95% confidence interval 0.06-0.68), P(trend) < 0.001]. After each patient with IgA nephropathy was randomly matched to a non-CKD participant on age (±5 years), gender, mean arterial pressure (±5 mmHg) and eGFR (±5 mL/min/1.73 m(2)), a multivariate conditional logistic regression model also verified their significant association [odds ratio 0.42 (95% confidence interval 0.18-1.00) and odds ratio 0.09 (95% confidence interval 0.01-0.73), P(trend) = 0.004]. MTR A2756G was not associated with slope of eGFR (mL/min/1.73 m(2)/year) in 230 patients with IgA nephropathy. CONCLUSION: MTR A2756G was associated with the development, but not progression, of IgA nephropathy.
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Authors | Ryohei Yamamoto, Yasuyuki Nagasawa, Tatsuya Shoji, Naoto Katakami, Kentaro Ohtoshi, Rieko Hayaishi-Okano, Yoshimitsu Yamasaki, Atsushi Yamauchi, Yoshiharu Tsubakihara, Enyu Imai, Hiromi Rakugi, Yoshitaka Isaka |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 27
Issue 3
Pg. 1020-30
(Mar 2012)
ISSN: 1460-2385 [Electronic] England |
PMID | 21737517
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Asian People
(genetics)
- Atherosclerosis
(complications, genetics)
- Case-Control Studies
- Cross-Sectional Studies
- Disease Progression
- Female
- Genetic Markers
(genetics)
- Genotype
- Glomerular Filtration Rate
- Glomerulonephritis, IGA
(etiology, pathology)
- Humans
- Kidney Failure, Chronic
- Male
- Polymorphism, Genetic
(genetics)
- Prognosis
- Proteinuria
(genetics, pathology)
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