Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: an open label pilot study.

Abstract

This study evaluated the efficacy of a 0.0584% hydrocortisone aceponate (HCA) spray (Cortavance(®); Virbac SA) in 10 cats with presumed allergic dermatitis. The cats initially received two sprays/100 cm(2) of skin once daily. Clinical lesions (a Feline Dermatitis Extent and Severity Index; FeDESI), pruritus (10 cm visual analog scale with grade descriptors) and owner assessments of efficacy, tolerance and ease of use (from 1=very poor to 5=excellent) were assessed every 14 days. The frequency of treatment was reduced after day 28 in cats with a >50% reduction in FeDESI and pruritus scores. One cat was lost to follow up at day 28 and two at day 42. Intention-to-treat data were analysed. The FeDESI [mean (SD): day 0, 42.2 (15.7) and day 56, 9.9 (11.7); P<0.0001] and pruritus scores [day 0, 61.2 mm (20.1) and day 56, 14.6 mm (16.1); P<0.0001] significantly decreased throughout the trial. The owner scores for tolerance [median (range): day 14, 4 (1-5) and day 56, 4 (3-5); P=0.003] and ease of administration [day 14, 3 (2-5) and day 56, 4 (2-5); P=0.02] significantly increased during the trial, but there was no significant change in efficacy scores [day 14, 4 (3-5) and day 56, 4 (2-5); P=0.5]. There were no adverse effects attributable to the HCA spray, no significant changes in weight [mean (SD): day 0, 5.0 kg (1.4) and day 56, 5.0 kg (1.6); P=0.51] and no significant changes in haematology, biochemistry or urinalysis (n=4). Six cats required every-other-day treatment and four required daily treatment. In conclusion, HCA spray appeared to be effective and safe in these cats, although it is not licensed for use in this species.

• Authors: Vanessa Schmidt, Laura M Buckley, Neil A McEwan, Christophe A Rème, Tim J Nuttall
• Journal: Veterinary dermatology (Vet Dermatol) Vol. 23 Issue 1 Pg. 11-6, e3-4 (Feb 2012) ISSN: 1365-3164 [Electronic] England
• PMID: 21718369 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2011 The Authors. Veterinary Dermatology © 2011 ESVD and ACVD.

Chemical References

• Aerosols
• Dermatologic Agents
• hydrocortisone aceponate
• Hydrocortisone

Topics

• Aerosols
• Animals
• Cat Diseases (drug therapy)
• Cats
• Dermatitis, Allergic Contact (drug therapy, veterinary)
• Dermatologic Agents (adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Hydrocortisone (adverse effects, analogs & derivatives, therapeutic use)
• Male
• Off-Label Use (veterinary)
• Pilot Projects
• Treatment Outcome