NRAMP1 polymorphism and susceptibility to lung tuberculosis in Surabaya, Indonesia.

Abstract	The aim of this study was to evaluate the role of three polymorphisms (D543N, TGTG deletion in 3' UTR, INT4 G/C) of NRAMP1 to susceptibility to lung tuberculosis (TB) disease. The results showed that homozygous TGTG deletion in 3'UTR of NRAMP1 was found more frequent in lung tuberculosis patients than in healthy nurses working in a TB ward. This 4 base deletion might cause malfunction of NRAMP1 protein so that it fails as Fe2+ ion transporter causing macrophage unable to eliminate Mycobacterium tuberculosis.
Authors	Jusak Nugraha, Rahayu Anggraini
Journal	The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 42 Issue 2 Pg. 338-41 (Mar 2011) ISSN: 0125-1562 [Print] Thailand
PMID	21710855 (Publication Type: Journal Article)
Chemical References	Cation Transport Proteins natural resistance-associated macrophage protein 1
Topics	Cation Transport Proteins (genetics) Genetic Predisposition to Disease Humans Indonesia (epidemiology) Polymorphism, Genetic Tuberculosis, Pulmonary (epidemiology, genetics)

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