Abstract | OBJECTIVE: METHODS: Between November 2007 and 28 May 2010, patients with head and neck cancer were treated with curative intent according to the concurrent chemoradiotherapy protocol (66-70 Gy at 2 Gy/day with cisplatin 80 mg/m(2) on Days 1, 22 and 43). Treatment courses, hematological data and other parameters were investigated, and the treatment completion rates and reasons for treatment failure were analyzed. RESULTS: Among the 28 patients, cisplatin was administered during the period of radiotherapy a total of 3 times in 9 (32%) patients, 2 times in 15 (54%) patients and only 1 time in 4 (14%) patients. Multiple regression analysis of the development of neutropenia at 3 weeks after the first cisplatin administration revealed that the serum albumin level was a significant explanatory variable (R(2)= 0.664, β = 0.517, P< 0.01). Pearson's product-moment correlation coefficient showed a strong correlation between the serum albumin level and the neutrophil count after 3 weeks (r = 0.605, P< 0.01). CONCLUSIONS: The treatment completion rate by this protocol was low in head and neck cancer patients even when the cisplatin dose was reduced to 80 mg/m(2). This tendency was seen in patients with a low serum albumin level.
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Authors | Masako Ishizuka, Yasushi Fujimoto, Yoshiyuki Itoh, Koichi Kitagawa, Motoki Sano, Yasuhiro Miyagawa, Atsushi Ando, Mariko Hiramatsu, Naoki Hirasawa, Shunichi Ishihara, Tsutomu Nakashima, Kiyofumi Yamada |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 41
Issue 8
Pg. 973-9
(Aug 2011)
ISSN: 1465-3621 [Electronic] England |
PMID | 21693483
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Hemoglobins
- Serum Albumin
- Cisplatin
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Topics |
- Adult
- Aged
- Anemia
(chemically induced)
- Antineoplastic Agents
(adverse effects, therapeutic use)
- Body Mass Index
- Carcinoma, Squamous Cell
(drug therapy, metabolism, pathology, radiotherapy)
- Cisplatin
(adverse effects, therapeutic use)
- Combined Modality Therapy
- Dermatitis
(etiology)
- Female
- Head and Neck Neoplasms
(drug therapy, metabolism, pathology, radiotherapy)
- Hemoglobins
(metabolism)
- Humans
- Leukocyte Count
- Leukopenia
(chemically induced)
- Male
- Middle Aged
- Mucositis
(etiology)
- Neutropenia
(chemically induced)
- Radiotherapy
(adverse effects)
- Regression Analysis
- Retrospective Studies
- Serum Albumin
(metabolism)
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