Primary colorectal lymphoma-clinical outcomes in a population-based series.

Abstract

PURPOSE:

The purpose of this study was to investigate the characteristics and the outcomes of primary colorectal lymphomas using a population-based registry.

METHODS:

All cases of colorectal lymphoma diagnosed between 1980 and 2007 were identified using a provincial cancer registry. Patients meeting Dawson's criteria and having a negative bone marrow biopsy were included.

RESULTS:

One hundred ten cases of colorectal lymphoma were identified, 43 met the inclusion criteria. The majority of patients was male (86%), and the median age at diagnosis was 62 (range 26-82) years. Tumors were mostly located in the cecum (51.1%) and rectum (20.9%). The 5-year overall survival rate calculated by the Kaplan-Meier method was 57%. Age under 60 was associated with a better median survival time (265 vs 54 months; p < 0.0001). The surgical treatment was associated with a better overall survival compared to medical treatment alone (110 vs 56 months; p = 0.083). Tumors located in the rectum were associated with a decreased overall survival (41 months vs 110 months; p = 0.065).

CONCLUSIONS:

Primary colorectal lymphoma is a rare disease. The age at diagnosis is an important predictor of outcome. Surgical resection may be associated with improved survival. Rectal lymphoma appears to be associated with a worse outcome and may warrant more aggressive therapy.

• Authors: Sebastien Drolet, Anthony R Maclean, Douglas A Stewart, Elijah Dixon, Elizabeth Oddone Paolucci, W Donald Buie
• Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (J Gastrointest Surg) Vol. 15 Issue 10 Pg. 1851-7 (Oct 2011) ISSN: 1873-4626 [Electronic] United States
• PMID: 21647770 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Alberta
• Colorectal Neoplasms (diagnosis, mortality, therapy)
• Combined Modality Therapy
• Female
• Humans
• Lymphoma (diagnosis, mortality, therapy)
• Male
• Middle Aged
• Neoplasm Staging
• Registries
• Retrospective Studies
• Risk Factors
• Survival Rate
• Treatment Outcome