Abstract | BACKGROUND: AIM: METHODS: Two cohorts of treatment-naïve patients with chronic hepatitis B (125 training and 92 validations) were consecutively and concurrently examined by percutaneous liver biopsy and transient elastography. Fibrosis was staged by Metavir (significant fibrosis = F ≥ 2; cirrhosis = F4) in ≥ 2 cm long liver tissue cores. RESULTS: A >13.1 kPa positive and a ≤ 9.4 kPa negative cut-off for cirrhosis had a >90% sensitivity and specificity, with an accuracy of 94%. The corresponding cut-offs for F ≥ 2 were >9.4 and ≤ 6.2 kPa, thus classifying 56% of patients with an overall accuracy of 90%. In the validation cohort, F4 and F ≥ 2 were predicted by the above transient elastography cut-offs with an overall accuracy >90%. In 165 patients with higher than upper limit of normal transaminase activity the dual cut-off algorithm of transient elastography was as accurate as in the 52 patients with normal alanine aminotransferase values in the prediction and exclusion of cirrhosis, only. CONCLUSIONS:
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Authors | M Viganò, S Paggi, P Lampertico, M Fraquelli, S Massironi, G Ronchi, C Rigamonti, D Conte, M Colombo |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 34
Issue 3
Pg. 353-62
(Aug 2011)
ISSN: 1365-2036 [Electronic] England |
PMID | 21631559
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Copyright | © 2011 Blackwell Publishing Ltd. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Alanine Transaminase
(blood)
- Algorithms
- Biopsy
(methods)
- Cohort Studies
- Elasticity Imaging Techniques
(methods)
- Female
- Hepatitis B, Chronic
(complications, diagnosis)
- Humans
- Liver Cirrhosis
(diagnosis, etiology)
- Male
- Middle Aged
- Predictive Value of Tests
- Regression Analysis
- Young Adult
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