Comparison of clinical and biologic features of Kingella kingae and Staphylococcus aureus arthritis at initial evaluation.

Abstract

We conducted a retrospective study comparing the presenting clinical and biologic features of 64 children who had septic arthritis caused by Kingella kingae with 26 children who had septic arthritis caused by Staphylococcus aureus. Children with K. kingae septic arthritis were significantly younger than those with S. aureus septic arthritis. Otherwise, there were no significant differences between the 2 groups with respect to fever, location, white blood cell count, synovial fluid cell count, C-reactive protein, or serum fibrinogen. However, the clinical course was significantly better for children with septic arthritis caused by K. kingae as evidenced by shorter hospitalization and fewer adverse events. Presumptive antibiotic therapy for septic arthritis in young infants should take into account both of these pathogens, even in case of mild presentation.

• Authors: Romain Basmaci, Mathie Lorrot, Philippe Bidet, Catherine Doit, Christine Vitoux, Georges Penneçot, Keyvan Mazda, Edouard Bingen, Brice Ilharreborde, Stéphane Bonacorsi
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 30 Issue 10 Pg. 902-4 (Oct 2011) ISSN: 1532-0987 [Electronic] United States
• PMID: 21552181 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adolescent
• Age Factors
• Anti-Bacterial Agents (therapeutic use)
• Arthritis, Infectious (microbiology, pathology)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Kingella kingae (isolation & purification, pathogenicity)
• Male
• Neisseriaceae Infections (microbiology, pathology)
• Retrospective Studies
• Sex Distribution
• Staphylococcal Infections (microbiology, pathology)
• Staphylococcus aureus (isolation & purification, pathogenicity)
• Time Factors
• Treatment Outcome