Mass-forming intrahepatic cholangiocarcinoma with marked enhancement on arterial-phase computed tomography reflects favorable surgical outcomes.

Abstract

BACKGROUND:

Outcomes after hepatectomy in patients with mass-forming (MF) type intrahepatic cholangiocarcinoma (ICC) with marked enhancement within the tumor on arterial-phase computed tomography (CT) scans have not been clarified in detail.

METHODS:

We retrospectively studied 140 patients with MF type ICC who underwent hepatectomy from 1989 through 2008. Surgical outcomes were compared between 25 patients with MF type ICC with marked enhancement within the tumor (hypervascular ICC) and 109 patients without enhancement within the tumor (hypovascular ICC) on arterial-phase CT scans.

RESULTS:

Portal invasion and intrahepatic metastasis were significantly lower in patients with hypervascular ICC than in those with hypovascular ICC. The 5-year survival rate was significantly higher in patients with hypervascular ICC (86%) than in patients with hypovascular ICC (27%, P < 0.0001). Multivariate analysis showed hypervascular ICC on arterial-phase CT scans, normal level of cancer-associated carbohydrate antigen 19-9, absence of portal invasion, and absence of intrahepatic metastasis of ICC to be significant independent prognostic factors for overall survival in patients with MF type ICC.

CONCLUSIONS:

MF type ICC with marked enhancement within the tumor on arterial CT scans showed a favorable surgical outcome due to its less invasive histopathologic characteristics in patients with MF type ICC.

• Authors: Shun-Ichi Ariizumi, Yoshihito Kotera, Yutaka Takahashi, Satoshi Katagiri, I-Pei Chen, Takehiro Ota, Masakazu Yamamoto
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 104 Issue 2 Pg. 130-9 (Aug 01 2011) ISSN: 1096-9098 [Electronic] United States
• PMID: 21448898 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Wiley-Liss, Inc.

Topics

• Aged
• Bile Duct Neoplasms (diagnostic imaging, surgery)
• Bile Ducts, Intrahepatic (diagnostic imaging, surgery)
• Cholangiocarcinoma (diagnostic imaging, surgery)
• Female
• Hepatectomy
• Humans
• Liver Neoplasms (diagnostic imaging, surgery)
• Male
• Middle Aged
• Prognosis
• Tomography, X-Ray Computed
• Treatment Outcome